Abstract Title:

Melatonin enhancement of the radiosensitivity of human breast cancer cells is associated with the modulation of proteins involved in estrogen biosynthesis.

Abstract Source:

Cancer Lett. 2015 Oct 21. Epub 2015 Oct 21. PMID: 26497762

Abstract Author(s):

Carolina Alonso-González, Alicia González, Carlos Martínez-Campa, Javier Menéndez-Menéndez, José Gómez-Arozamena, Angela García-Vidal, Samuel Cos

Article Affiliation:

Carolina Alonso-González

Abstract:

Enhancing the radiosensitivity of cancer cells is one of the most important tasks in clinical radiobiology. Endocrine therapy and radiotherapy are two cancer treatment modalities which are often given together in patients with locally-advanced breast cancer and positive hormone-receptor status. Oncostatic actions of melatonin are relevant on estrogen-dependent mammary tumors. In the present study, we wanted to evaluate the effects of the combination of ionizing radiation and melatonin on proteins involved in estrogen biosynthesis in breast cancer cells. We demonstrated a role of melatonin in mediating the sensitization of human breast cancer cells to the ionizing radiation by decreasing around a 50% the activity and expression of proteins involved in the synthesis of estrogens in these cells. Thus, melatonin pretreatment before radiation reduces the amount of active estrogens at cancer cell level. Melatonin 1 nM induced 2-fold change in p53 expression as compared to radiation alone. The regulatory action of melatonin on p53 could be a link between melatonin and its modulatory action on sensitivity of breast cancer cells to ionizing radiation. These findings may have implications for designing clinical trials using melatonin and radiotherapy.

Study Type : In Vitro Study
Additional Links
Pharmacological Actions : Radiosensitizer : CK(244) : AC(142)

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