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Article Publish Status: FREE
Abstract Title:

Melatonin increases survival and inhibits oxidative and amyloid pathology in a transgenic model of Alzheimer's disease.

Abstract Source:

J Neurochem. 2003 Jun ;85(5):1101-8. PMID: 12753069

Abstract Author(s):

Etsuro Matsubara, Tara Bryant-Thomas, Javier Pacheco Quinto, Tracey L Henry, Burkhard Poeggeler, Donald Herbert, Felix Cruz-Sanchez, Yau-Jan Chyan, Mark A Smith, George Perry, Mikio Shoji, Koji Abe, Anna Leone, Inge Grundke-Ikbal, Glen L Wilson, Jorge Ghiso, Christina Williams, Lorenzo M Refolo, Miguel A Pappolla, Daniel G Chain, Eyal Neria

Article Affiliation:

Etsuro Matsubara

Abstract:

Increased levels of a 40-42 amino-acid peptide called the amyloid beta protein (A beta) and evidence of oxidative damage are early neuropathological markers of Alzheimer's disease (AD). Previous investigations have demonstrated that melatonin is decreased during the aging process and that patients with AD have more profound reductions of this hormone. It has also been recently shown that melatonin protects neuronal cells from A beta-mediated oxidative damage and inhibits the formation of amyloid fibrils in vitro. However, a direct relationship between melatonin and the biochemical pathology of AD had not been demonstrated. We used a transgenic mouse model of Alzheimer's amyloidosis and monitored over time the effects of administering melatonin on brain levels of A beta, abnormal protein nitration, and survival of the mice. We report here that administration of melatonin partially inhibited the expected time-dependent elevation of beta-amyloid, reduced abnormal nitration of proteins, and increased survival in the treated transgenic mice. These findings may bear relevance to the pathogenesis and therapy of AD.

Study Type : Transgenic Animal Study

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