Article Publish Status: FREE
Abstract Title:

The effect of a natural molecule in ovary ischemia reperfusion damage: does lycopene protect ovary?

Abstract Source:

Exp Anim. 2020 Sep 11. Epub 2020 Sep 11. PMID: 32921696

Abstract Author(s):

Demet Aydogan Kirmizi, Emre Baser, Aslı Okan, Mustafa Kara, Ethem Serdar Yalvac, Zuleyha Doganyigit

Article Affiliation:

Demet Aydogan Kirmizi


Ovarian ischemia is a gynecological emergency case that occurs as a result of ovarian torsion. Oxidative stress plays a central role in the development of ischemia/reperfusion (IR) injuries. Lycopene (LYC) is a lipophilic, natural carotenoid well known for its antioxidant properties. This study provides information on the potential applications of lycopene. The Wistar Albino rats were distributed into six groups: Sham group [only a laparotomy was performed], Control group [laparotomy and intraperitoneal dissolvent (olive oil)], IR group , IR + olive oil group, IR+LYC 2.5 mg/kg/dose, intraperitoneal group, IR+LYC 5 mg/kg/dose intraperitoneal group. Evaluated in terms of histopathological changes, tissue malondialdehyde levels (MDA), ovarian expressions of phosphorylated nuclear factor-kappa B (p-NF-κB) and the TUNEL method was utilized to show apoptosis of ovarian tissue. There was a significant decrease in MDA, p-NF-κB values and the proportion of apoptotic cells assessed by TUNEL compared to the group that did not receive intraperitoneal LYC in rat injury with IR damage (p<0.05). In histopathological damage scoring, it was observed that the cell damage was significantly reduced in LYC-administered groups. LYC showed significant ameliorative effects on ovary injury caused by IR through acting as an antioxidant, antiinflammatory, and antiapoptotic agent.

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