Article Publish Status: FREE
Abstract Title:

Lupeol, a Dietary Triterpene, Enhances Wound Healing in Streptozotocin-Induced Hyperglycemic Rats with Modulatory Effects on Inflammation, Oxidative Stress, and Angiogenesis.

Abstract Source:

Oxid Med Cell Longev. 2019 ;2019:3182627. Epub 2019 May 9. PMID: 31210838

Abstract Author(s):

Fernando Pereira Beserra, Ana Júlia Vieira, Lucas Fernando Sérgio Gushiken, Eduardo Oliveira de Souza, Maria Fernanda Hussni, Carlos Alberto Hussni, Rafael Henrique Nóbrega, Emanuel Ricardo Monteiro Martinez, Christopher John Jackson, Gabriela Lemos de Azevedo Maia, Ariane Leite Rozza, Cláudia Helena Pellizzon

Article Affiliation:

Fernando Pereira Beserra


Impaired wound healing is a debilitating complication of diabetes that leads to significant morbidity, particularly foot ulcers. Natural products have shown to be effective in treating skin wounds. Lupeol is known to stimulate angiogenesis, fibroblast proliferation, and expressions of cytokines and growth factors involved in wound healing. The study is performed to evaluate the wound healing activity of lupeol in streptozotocin-induced hyperglycemic rats by macroscopical, histological, immunohistochemical, immunoenzymatic, and molecular methods. Percentage of wound closure and contraction was increased in the lupeol-treated group when compared to the Lanette group. Histopathological observation revealed decreased inflammatory cell infiltration and increased proliferation of fibroblasts, vascularization, and deposition of collagen fibers after lupeol treatment. Immunohistochemical analyses showed decreased intensity of NF-B and increased intensity of FGF-2, TGF-1, and collagen III. ELISA results revealed downregulated IL-6 levels and upregulated IL-10 levels in response to lupeol. The mRNA expression levels of,, andwere significantly increased in response to lupeol as compared to Lanette whereasandlevels were decreased in relation to insulin and lupeol treatment. These findings indicate that lupeol possesses wound healing potential in hyperglycemic conditions and may be useful as a treatment for chronic wounds in diabetic patients.

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