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Abstract Title:

Role of Vitamin D in Hospitalized Children With Lower Tract Acute Respiratory Infections.

Abstract Source:

J Pediatr Gastroenterol Nutr. 2016 Mar ;62(3):479-85. PMID: 26465790

Abstract Author(s):

Miriam Cebey-López, Jacobo Pardo-Seco, Alberto Gómez-Carballa, Nazareth Martinón-Torres, Irene Rivero-Calle, Antonio Justicia, Lorenzo Redondo, José María Martinón-Sánchez, María Del Carmen Martínez-Padilla, Francisco Giménez-Sánchez, Antonio Salas, Federico Martinón-Torres,

Article Affiliation:

Miriam Cebey-López

Abstract:

BACKGROUND: Vitamin D is known to have modulatory actions in the immune system. Its influence on the severity of lower tract acute respiratory infections (LT-ARIs) is unclear.

OBJECTIVES: The aim of the present study was to evaluate the role of vitamin D on LT-ARI in paediatric patients.

METHODS: Children admitted to hospital with LT-ARI were prospectively recruited through the GENDRES network (March 2009-May 2013). The 25-hydroxyvitamin D (25-OHD) levels were measured by immunoassay. The severity of the illness was evaluated according to clinical scales, length of hospital stay, ventilatory requirements, and pediatric intensive care unit admission.

RESULTS: A total of 347 patients with a median (interquartile range) age of 8.4 (2.6-21.1) months were included. The mean (SD) 25-OHD levels in our series were 27.1 (11.3) ng/mL. In this study, a cutoff value of≥30 ng/mL was considered optimal vitamin status. Patients with 25-OHD levels<20 ng/mL were at a higher risk of showing severe signs of respiratory difficulties (OR 5.065, 95% confidence interval 1.998-12.842; P = 0.001) than patients with normal values, and had a 117% higher risk of oxygen necessity and 217% higher risk of ventilatory requirement than those patients with normal values. An inverse correlation was found between 25-OHD levels and the severity in the evaluated scales. 25-OHD levels did not influence PICU admission rate or length of hospital stay.

CONCLUSIONS: 25-OHD levels of children admitted because of a LT-ARI are<30 ng/mL. Lower levels of 25-OHD were found to be correlated with severity of the disease. The possible role of abnormal 25-OHD levels as a facilitator or consequence of the infection needs further evaluation.

Study Type : Human Study

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