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Article Publish Status: FREE
Abstract Title:

Low-dose Bisphenol-A Promotes Epigenetic Changes atPromoter in Adipose Precursor Cells.

Abstract Source:

Nutrients. 2020 Nov 13 ;12(11). Epub 2020 Nov 13. PMID: 33203037

Abstract Author(s):

Michele Longo, Federica Zatterale, Jamal Naderi, Cecilia Nigro, Francesco Oriente, Pietro Formisano, Claudia Miele, Francesco Beguinot

Article Affiliation:

Michele Longo

Abstract:

Exposure to endocrine-disrupting chemicals such as Bisphenol-A (BPA) is associated with an increase in obesity prevalence. Diet is the primary cause of human exposure to this contaminant. BPA promotes obesity by inducing adipocyte dysfunction and altering adipogenesis. Contradictory evidence and unanswered questions are reported in the literature concerning the BPA effects on adipogenesis. To clarify this issue, we tested the effects of prolonged low-dose BPA exposure on different phases of adipogenesis in committedand uncommittedpreadipocytes. Our findings show that BPA effects on the adipogenesis are mediated by epigenetic mechanisms by reducing peroxisome proliferator-activated receptor gamma () promoter methylation in preadipocytes. Nevertheless, in BPA-exposed,expression only transiently increases as lipid accumulation at day 4 of differentiation, without altering the adipogenic potential of the precursor cells. In the absence of differentiation mix, BPA does not make thean in vitro model of spontaneous adipogenesis and the effects on theexpression are still limited at day 4 of differentiation. Furthermore, BPA exposure does not commit theto the adipocyte lineage, althoughoverexpression is more evident both in preadipocytes and during the adipocyte differentiation. Interestingly, termination of the BPA exposure restores thepromoter methylation and inflammatory profile of thecells. This study shows that BPA induces epigenetic changes in a key adipogenic gene. These modifications are reversible and do not affect preadipocyte commitment and/or differentiation. We identify an alternative transcriptional mechanism by which BPA affects gene expression and demonstrate how the challenge of preventing exposure is fundamental for human health.

Study Type : In Vitro Study

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