Lonicera japonica flower bud may be useful for treating Citrobacter rodentium-induced digestive tract infection. - GreenMedInfo Summary

Although antibiotic therapy is currently a gold standard for bacterial infections, it is not used for severe diseases like enterohemorrhagic, in which the Shiga toxin is overproduced by antibiotic action. Theflower bud (LJF) is an herbal component used against purulent diseases in traditional Japanese and Chinese medicine. We investigated the effects of LJF extract (LJFE) on-induced digestive tract infection in a mouse model.and LJFE were orally administered to C57BL/6 mice. The survival rate and bacterial colonization in the large intestine, mesenteric lymph node, and blood of mice were evaluated. Cytokines secreted from intraperitoneal macrophages of LJFE-treated mice were measured using ELISA. Moreover, the phagocytic activity of intraperitoneal macrophages againstwas compared between LJFE- or chlorogenic acid (CGA)-treated mice.LJFE significantly increased the survival rate and decreasedcolonization in mice. Moreover, the values of tumor necrosis factor-α, interleukin-1β, and interferon-γ secreted from macrophages were increased following LJFE treatment. While macrophages of LJFE-treated mice showed a significant phagocytic activity, macrophages of CGA-treated mice only showed a phagocytic tendency.LJF may be useful for treating-induced digestive tract infection.