Abstract Title:

Leukocyte telomere length and marital status among middle-aged adults.

Abstract Source:

Age Ageing. 2011 Jan ;40(1):73-8. Epub 2010 Sep 4. PMID: 20817935

Abstract Author(s):

Arch G Mainous, Charles J Everett, Vanessa A Diaz, Richard Baker, Massimo Mangino, Veryan Codd, Nilesh J Samani

Article Affiliation:

Medical University of South Carolina, Family Medicine, Charleston, SC 29425, USA. mainouag@musc.edu

Abstract:

BACKGROUND: being unmarried is associated with worse health and increased mortality risk. Telomere length has emerged as a marker for biological ageing but it is unclear how telomere length relates to marital status.

OBJECTIVE: to examine the relationship between telomere length and marital status in a sample of middle-aged adults. Design and subjects: cross-sectional analysis among 321 adults aged 40-64 years.

METHODS: telomere length was measured by PCR (T/S ratio). Participants provided information on healthy lifestyle activities including smoking, alcohol use, diet, exercise, obesity as well as social support.

RESULTS: participants married or living with a partner had a mean T/S ratio of 1.70 and those widowed, divorced, separated or never married had a mean T/S ratio of 1.58 in a model adjusted for age, gender and race/ethnicity (P<0.001). When the analysis was further adjusted for diet, alcohol consumption, exercise, smoking, social support, poverty and obesity, persons married or living with a partner had a higher mean T/S ratio of 1.69 than their unmarried counterparts (1.59) (P = 0.004).

CONCLUSIONS: these results indicate that unmarried individuals have shorter telomeres. This relationship between marital status and telomere length is independent of presumed benefits of marriage such as social support and a healthier lifestyle.

Study Type : Human Study
Additional Links
Pharmacological Actions : Telomere Protective : CK(83) : AC(10)

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