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Abstract Title:

Transcranial LED therapy on amyloid-β toxin 25-35 in the hippocampal region of rats.

Abstract Source:

Lasers Med Sci. 2017 May ;32(4):749-756. Epub 2017 Mar 2. PMID: 28255783

Abstract Author(s):

Camila da Luz Eltchechem, Afonso Shiguemi Inoue Salgado, Renato Amaro Zângaro, Mário César da Silva Pereira, Ivo Ilvan Kerppers, Luis Augusto da Silva, Rodolfo Borges Parreira

Article Affiliation:

Camila da Luz Eltchechem

Abstract:

Excessive Aβ deposition in the brain is associated with the formation of senile plaques, and their diffuse distribution is related to Alzheimer's disease. Thirty rats (EG) were irradiated with light-emitting diode (photobiomodulation (PBM)) in the frontal region of the skull after being inoculated with the Aβtoxin in the hippocampus; 30 rats were used as the control group (CG). The analysis was conducted at 7, 14, and 21 days after irradiation. We observed a decreased in Aβ deposits in treated animals compared with animals in the CG. The behavioral and motor assessment revealed that the EG group covered a larger ground distance and explored the open field than the CG group on days 14 and 21 (p < 0.05). The EG group was statistically significant in the spatial memory test compared to the CG group on day 14. The use of PBM significantly reduced the presence of Aβ plaques and improved spatial memory and behavioral and motor skills in treated animals on day 21.

Study Type : Animal Study

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