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Abstract Title:

The effect of aqueous extract of Lavandula officinalis to reduce cholesterol, triglyceride and other lipid metabolites on female BALB/c mice.

Abstract Source:

Clin Investig Arterioscler. 2020 Apr 11. Epub 2020 Apr 11. PMID: 32291194

Abstract Author(s):

Seyedeh Marziyeh Hosseini, Parvin Torabzadeh, Seyedeh Saeedeh Hosseini, Mohammad Karimli, Soodeh Sharifian, Mona Mahjouri Kafshgari, Keyvan Taheri, Mahdis Ebrahimzadeh

Article Affiliation:

Seyedeh Marziyeh Hosseini

Abstract:

BACKGROUND: Hyperlipidemia is a prevalent disorder and a main component of the metabolic syndrome resulting from various factors. The aerial parts and flowers of Lavandula officinalis possesses antioxidant activity, therefore, in this study; the effects of L. officinalis extract were investigated on serum lipid levels of mice.

METHODS: Experimental mature female BALB/c mice were treated with 100, 300 or 500mg/kg/day of lavender aqueous extract or distilled water for 15 days via intraperitoneally injections. At the end of 15th day, the serum biochemical parameters include cholesterol, triglyceride, HDL and LDL levels as well as the liver cell function test were determined.

RESULTS: The aqueous extract of lavender significantly decreased serum cholesterol and LDL levels. Serum cholesterol level was lower in the 300 and 500mg/kg/day experimental groups when compared with the control group. In liver histology evaluation, fat accumulation was not observed in the experimental group, which treated with high-fat foods and receiving high doses of extract.

CONCLUSION: L. officinalis extract exerts a hypolipidemic effect in studied groups, however, further phytochemical and biological tests are suggested to determine the active chemical constituent responsible for these activities.

Study Type : Animal Study
Additional Links
Pharmacological Actions : Hypolipidemic : CK(3189) : AC(707)

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