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Abstract Title:

Lactoferrin-derived peptides antimicrobial activity: anexperiment.

Abstract Source:

Nat Prod Res. 2020 Sep 14:1-5. Epub 2020 Sep 14. PMID: 32927978

Abstract Author(s):

Elena Biasibetti, Silvia Rapacioli, Natascia Bruni, Elisa Martello

Article Affiliation:

Elena Biasibetti

Abstract:

Antibiotic resistance is a global problem, searching for new antimicrobial agents is an urgent need. In this study,antibacterial and antimicrobial effects of milk-derived antimicrobial agents, lactoferrin-derived peptides, lactoferricin (Lfc) and lactoferrampin (Lfa) (alone or in combination) and their association with natural extracts have been explored. The assessment of antimicrobial activity was based on two measurements: Minimum Inhibitory Concentration and Fractional Inhibitory Concentration indexes. Lfc alone is more suitable for inhibitingandwhile Lfa against, a synergistic effect of the two peptides against all the three pathogens has been detected. A strong synergy of all the natural extracts with Lfc and Lfa solution against selected microorganismswas pointed out. Our results suggest that natural-derived compounds, such as milk peptides and vegetal extracts could be promising tools to treat moderate fungal and bacterial infections.

Study Type : In Vitro Study

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