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Article Publish Status: FREE
Abstract Title:

A single bacterium restores the microbiome dysbiosis to protect bones from destruction in a rat model of rheumatoid arthritis.

Abstract Source:

Microbiome. 2019 07 17 ;7(1):107. Epub 2019 Jul 17. PMID: 31315667

Abstract Author(s):

Hudan Pan, Ruijin Guo, Yanmei Ju, Qi Wang, Jie Zhu, Ying Xie, Yanfang Zheng, Ting Li, Zhongqiu Liu, Linlin Lu, Fei Li, Bin Tong, Liang Xiao, Xun Xu, Elaine Lai-Han Leung, Runze Li, Huanming Yang, Jian Wang, Hua Zhou, Huijue Jia, Liang Liu

Article Affiliation:

Hudan Pan

Abstract:

BACKGROUND: Early treatment is key for optimizing the therapeutic success of drugs, and the current initiating treatment that blocks the progression of bone destruction during the pre-arthritic stages remains unsatisfactory. The microbial disorder in rheumatoid arthritis (RA) patients is significantly reversed with effective treatment. Modulating aberrant gut microbiomes into a healthy state is a potential therapeutic approach for preventing bone damage.

RESULTS: By using metagenomic shotgun sequencing and a metagenome-wide association study, we assessed the effect of Lactobacillus casei (L. casei) on the induction of arthritis as well as on the associated gut microbiota and immune disorders in adjuvant-induced arthritis (AIA) rats. Treatment of AIA rats with L. casei inhibited joint swelling, lowered arthritis scores, and prevented bone destruction. Along with the relief of arthritis symptoms, dysbiosis in the microbiome of arthritic rats was significantly reduced after L. casei intervention. The relative abundance of AIA-decreased Lactobacillus strains, including Lactobacillus hominis, Lactobacillus reuteri, and Lactobacillus vaginalis, were restored to normal and Lactobacillus acidophilus was upregulated by the administration of L. casei to the AIA rats. Moreover, L. casei downregulated the expression of pro-inflammatory cytokines, which are closely linked to the effect of the L. casei treatment-associated microbes. Functionally, the maintenance of the redox balance of oxidative stress was involved in the improvement in the L. casei-treated AIA rats.

CONCLUSION: A single bacterium, L. casei (ATCC334), was able to significantly suppress the induction of AIA and protect bones from destruction in AIA rats by restoring the microbiome dysbiosis in the gut, indicating that using probiotics may be a promising strategy for treating RA, especially in the early stage of the disease.

Study Type : Animal Study

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Sayer Ji
Founder of GreenMedInfo.com

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