Article Publish Status: FREE
Abstract Title:

L-Carnitine-supplementation in advanced pancreatic cancer (CARPAN)--a randomized multicentre trial.

Abstract Source:

Nutr J. 2012 ;11:52. Epub 2012 Jul 23. PMID: 22824168

Abstract Author(s):

Matthias Kraft, Kathleen Kraft, Simone Gärtner, Julia Mayerle, Peter Simon, Eckhard Weber, Kerstin Schütte, Jens Stieler, Heide Koula-Jenik, Peter Holzhauer, Uwe Gröber, Georg Engel, Cornelia Müller, You-Shan Feng, Ali Aghdassi, Claudia Nitsche, Peter Malfertheiner, Maciej Patrzyk, Thomas Kohlmann, Markus M Lerch

Article Affiliation:

Matthias Kraft

Abstract:

BACKGROUND: Cachexia, a>10% loss of body-weight, is one factor determining the poor prognosis of pancreatic cancer. Deficiency of L-Carnitine has been proposed to cause cancer cachexia.

FINDINGS: We screened 152 and enrolled 72 patients suffering from advanced pancreatic cancer in a prospective, multi-centre, placebo-controlled, randomized and double-blinded trial to receive oral L-Carnitine (4 g) or placebo for 12 weeks. At entry patients reported a mean weight loss of 12 ± 2.5 (SEM) kg. During treatment body-mass-index increased by 3.4 ± 1.4% under L-Carnitine and decreased (-1.5 ± 1.4%) in controls (p < 0.05). Moreover, nutritional status (body cell mass, body fat) and quality-of-life parameters improved under L-Carnitine. There was a trend towards an increased overall survival in the L-Carnitine group (median 519 ± 50 d versus 399 ± 43 d, not significant) and towards a reduced hospital-stay (36 ± 4d versus 41 ± 9d,n.s.).

CONCLUSION: While these data are preliminary and need confirmation they indicate that patients with pancreatic cancer may have a clinically relevant benefit from the inexpensive and well tolerated oral supplementation of L-Carnitine.

Study Type : Human Study

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