Abstract Title:

Endothelial dysfunction in MELAS improved by l-arginine supplementation.

Abstract Source:

Neurology. 2006 Jun 13;66(11):1766-9. PMID: 16769961

Abstract Author(s):

Y Koga, Y Akita, N Junko, S Yatsuga, N Povalko, R Fukiyama, M Ishii, T Matsuishi

Article Affiliation:

Department of Pediatrics and Child Health, Kurume University School of Medicine, Fukuoka, Japan. yasukoga@med.kurume-u.ac.jp

Abstract:

The authors evaluated endothelial function in patients with MELAS (mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke) by flow-mediated vasodilation (FMD) and found a significant decrease vs controls. Two years of supplementation with oral l-arginine, a nitric oxide precursor, significantly improved endothelial function to control levels and was harmonized with the normalized plasma levels of l-arginine in patients. l-Arginine therapy improved endothelial dysfunction and showed promise in treating strokelike episodes in MELAS.

Study Type : Human Study

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