n/a
Article Publish Status: FREE
Abstract Title:

Korean Red Ginseng Extract Increases Apoptosis by Activation of the Noxa Pathway in Colorectal Cancer.

Abstract Source:

Nutrients. 2019 Aug 29 ;11(9). Epub 2019 Aug 29. PMID: 31470581

Abstract Author(s):

Yoon A Jeong, Bo Ram Kim, Dae Young Kim, Soyeon Jeong, Yoo Jin Na, Jung Lim Kim, Hye Kyeong Yun, Bu Gyeom Kim, Seong Hye Park, Min Jee Jo, Sun Il Lee, Byung-Cheol Han, Dae-Hee Lee, Sang Cheul Oh

Article Affiliation:

Yoon A Jeong

Abstract:

BACKGROUND: Although the anticancer activity of Korean Red Ginseng (KRG) has been known in various cancers, the mechanism of KRG-induced apoptosis is unknown in colorectal cancer (CRC). In our study, we examined whether KRG induces apoptosis in CRC cells.

METHODS: In the cell viability assay, the concentration of the appropriate KRG extracts was fixed at 2.5 mg/mL in numerous CRC cells. This fixed concentration was in other experiments, and it was confirmed that the KRG extracts induce apoptosis in CRC cells.

RESULTS: We found that KRG induced Noxa activation and apoptosis and increased endoplasmic reticulum stress via reactive oxygen species production. This indicated that KRG efficiently enhanced cell death in CRC cells.

CONCLUSION: Our results show that KRG can be used as a possible anticancer drug for patients with CRC.

Study Type : In Vitro Study

Print Options


Key Research Topics

Sayer Ji
Founder of GreenMedInfo.com

Subscribe to our informative Newsletter & get Nature's Evidence-Based Pharmacy

Our newsletter serves 500,000 with essential news, research & healthy tips, daily.

Download Now

500+ pages of Natural Medicine Alternatives and Information.

This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.

© Copyright 2008-2021 GreenMedInfo.com, Journal Articles copyright of original owners, MeSH copyright NLM.