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Article Publish Status: FREE
Abstract Title:

Promising Effect of a New Ketogenic Diet Regimen in Patients with Advanced Cancer.

Abstract Source:

Nutrients. 2020 May 19 ;12(5). Epub 2020 May 19. PMID: 32438645

Abstract Author(s):

Keisuke Hagihara, Katsufumi Kajimoto, Satoshi Osaga, Naoko Nagai, Eku Shimosegawa, Hideyuki Nakata, Hitomi Saito, Mai Nakano, Mariko Takeuchi, Hideaki Kanki, Kuriko Kagitani-Shimono, Takashi Kijima

Article Affiliation:

Keisuke Hagihara

Abstract:

A ketogenic diet is expected to be an effective support therapy for patients with cancer, but the degree and duration of carbohydrate restriction are unclear. We performed a case series study of a new ketogenic diet regimen in patients with different types of stage IV cancer. Carbohydrates were restricted to 10 g/day during week one, 20 g/day from week two for three months, and 30 g/day thereafter. A total of 55 patients participated in the study, and data from 37 patients administered the ketogenic diet for three months were analyzed. No severe adverse events associated with the diet were observed. Total ketone bodies increased significantly, and both fasting blood sugar and insulin levels were suppressed significantly for three months after completion of the study. Five patients showed a partial response on Positron emission tomography-computed tomography (PET-CT) at three months. Three and seven patients showed complete and partial responses, respectively at one year. Median survival was 32.2 (maximum: 80.1) months, and the three-year survival rate was 44.5%. After three months on the ketogenic diet, the serum Alb, BS, and CRP (ABC) score could be used to stratify the patients into groups with significantly different survival rates (<0.001, log-rank test). Our ketogenic diet regimen is considered to be a promising support therapy for patients with different types of advanced cancer.

Study Type : Human Study

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