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Abstract Title:

The Impact of a Polyphenol-Rich Extract from the Berries ofL. on Collagen Metabolism in the Liver: A Study in an In Vivo Model of Human Environmental Exposure to Cadmium.

Abstract Source:

Nutrients. 2020 Sep 10 ;12(9). Epub 2020 Sep 10. PMID: 32927885

Abstract Author(s):

Magdalena Kozłowska, Małgorzata M Brzóska, Joanna Rogalska, Anna Galicka

Article Affiliation:

Magdalena Kozłowska

Abstract:

This study examined whether a polyphenol-rich extract from the berries ofL. (AE; chokeberries) may protect from the impact of cadmium (Cd) on the metabolism of collagen in the liver. The study was conducted in an experimental model (rats that were fed a diet containing 1 or 5 mg Cd/kg for 3-24 months) of human exposure to this xenobiotic during a lifetime. The concentration of total collagen and the expression of collagen types I and III at the mRNA and protein levels, as well as the concentrations of matrix metalloproteinases (MMP-1 and MMP-2) and their tissue inhibitors (TIMP-1 and TIMP-2), were assayed. The administration of Cd and/or AE had only a slight and temporary impact on the concentration of total collagen in the liver. The supplementation with AE significantly prevented Cd-mediated changes in the expression of collagen types I and III at the mRNA and protein levels and their ratio (collagen III/collagen I), as well as a rise in the concentrations of MMPs and TIMPs in this organ. The results allow the conclusion that the intake of chokeberry products in the case of Cd intoxication may be effective in prevention from this xenobiotic-induced disturbance in collagen homeostasis in the liver.

Study Type : Animal Study

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