Abstract Title:

Inhibition of interleukin-12 production in lipopolysaccharide-activated macrophages by curcumin.

Abstract Source:

Eur J Pharmacol. 1999 Nov 19;384(2-3):191-5. PMID: 10611441

Abstract Author(s):

B Y Kang, S W Chung, W Chung, S Im, S Y Hwang, T S Kim

Article Affiliation:

College of Pharmacy and Research Institute of Drug Development, Chonnam National University, Kwangju, South Korea.

Abstract:

Pharmacological control of interleukin-12 production may be a key therapeutic strategy for modulating immunological diseases dominated by type-1 cytokine responses. In this study we investigated the effects of curcumin (1,7-bis[4-hydroxy-3-methoxyphenyl]-1, 6-heptadiene-3,5-dione) on the production of interleukin-12 from mouse macrophages stimulated with lipopolysaccharide. Curcumin potently inhibited the production of interleukin-12 in a dose-dependent manner. The effect of curcumin on interleukin-12 p40 promoter activation was analyzed by transfecting RAW264.7 monocytic cells with p40 promoter/reporter constructs. The repressive effect mapped to a region in the p40 promoter containing a binding site for nuclear factor kappaB (p40-kappaB). Furthermore, activation of macrophages by lipopolysaccharide resulted in markedly enhanced binding activity to the kappaB site, which significantly decreased upon addition of curcumin. These results suggest that curcumin-induced inhibition of interleukin-12 production in macrophages may explain some of the biological effects of curcumin including its anti-inflammatory activity.

Study Type : In Vitro Study

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