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Article Publish Status: FREE
Abstract Title:

Serological examination of IgE- and IgG-specific antibodies to egg protein during influenza virus immunization.

Abstract Source:

Epidemiol Infect. 1988 Apr ;100(2):291-9. PMID: 3356225

Abstract Author(s):

N Yamane, H Uemura

Article Affiliation:

N Yamane

Abstract:

The concentrations of serum IgE (PRIST) and IgE- and IgG-specific antibodies to egg protein were determined in paired sera taken from students who had received influenza virus vaccine. Although persons who gave a history of allergy to egg or to chicken feathers were excluded, 10-16% of vaccinees possessed higher titres of serum IgE and IgE-specific antibody (RAST) to egg white (F1) allergen before vaccination. The titres of IgG-specific antibody to egg protein (ovalbumin and ovomucoid antigens) were negligible, and did not show any significant response after vaccination. In contrast, IgE-specific antibody to F1 allergen rose significantly in a considerable number of the vaccines. The results obtained indicate possible contamination of vaccine products with allergens of egg origin and a potential risk of allergic manifestation after influenza vaccination.

Study Type : Human Study

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Sayer Ji
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