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Article Publish Status: FREE
Abstract Title:

The immunostimulatory activity of polysaccharides from.

Abstract Source:

PeerJ. 2020 ;8:e8294. Epub 2020 Jan 29. PMID: 32030319

Abstract Author(s):

Adila Aipire, Mahepali Mahabati, Shanshan Cai, Xianxian Wei, Pengfei Yuan, Alimu Aimaier, Xinhui Wang, Jinyao Li

Article Affiliation:

Adila Aipire

Abstract:

Background: The enhancement of immunity is very important for immunocompromised patients such as cancer patients with radiotherapy or chemotherapy.has been used as food and medicine for a long history.polysaccharides (GUPS) were prepared and its immunostimulatory effects were investigated.

Methods: Human monocyte-derived dendritic cells (DCs) and murine bone marrow-derived DCs were treated with different concentrations of GUPS. The DCs maturation and cytokine production were analyzed by flow cytometry and ELISA, respectively. Inhibitors and Western blot were used to study the mechanism of GUPS. The immunostimulatory effects of GUPS were further evaluated by naïve mouse model and immunosuppressive mouse model induced by cyclophosphamide.

Results: GUPS significantly promoted the maturation and cytokine secretion of human monocyte-derived DCs and murine bone marrow-derived DCs through TLR4 and down-stream p38, JNK and NF-B signaling pathways. Interestingly, the migration of GUPS treated-DCs to lymph node was increased. In the mouse model, GUPS increased IL-12 production in sera but not for TNF-α. Moreover, GUPS ameliorated the side effect of cyclophosphamide and improved the immunity of immunosuppressive mice induced by cyclophosphamide. These results suggested that GUPS might be used for cancer therapy to ameliorate the side effect of chemotherapy and enhance the immunity.

Study Type : In Vitro Study
Additional Links
Pharmacological Actions : Immunostimulatory : CK(442) : AC(114)
Additional Keywords : Polysaccharides : CK(5) : AC(3)

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Sayer Ji
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