Abstract Title:

Immunomodulation by pycnogenol in retrovirus-infected or ethanol-fed mice.

Abstract Source:

Life Sci. 1996 ;58(5):PL 87-96. PMID: 8594302

Abstract Author(s):

J E Cheshier, S Ardestani-Kaboudanian, B Liang, M Araghiniknam, S Chung, L Lane, A Castro, R R Watson

Article Affiliation:

J E Cheshier

Abstract:

Pycnogenol is a commercial mixture of bioflavonoids that exhibits antioxidative activity. The effects of dietary pycnogenol on immune dysfunction in normal mice as well as those fed ethanol or infected with the LP-BM5 murine retrovirus were determined. The ethanol consumption and retrovirus infection caused abnormalities in the function and/or structure of a broad array of cells involved in humoral and cellular immunity. Pycnogenol enhanced in vitro IL-2 production by mitogen-stimulated splenocytes if its production was suppressed in ethanol-fed or retrovirus-infected mice. Mitogenesis of splenocytes did not show a significant change in mice treated with pycnogenol. It reduced the elevated levels of interleukin-6 produced in vitro by cells from retrovirus infected mice and IL-10 secreted by spleen cells from mice consuming ethanol. Natural killer cell cytotoxicity was increased with pycnogenol treatment.

Study Type : Animal Study

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