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Article Publish Status: FREE
Abstract Title:

Immunomodulating activity of ginsenoside Rg1 from Panax ginseng.

Abstract Source:

Jpn J Pharmacol. 1990 Dec ;54(4):447-54. PMID: 2087006

Abstract Author(s):

B Kenarova, H Neychev, C Hadjiivanova, V D Petkov

Article Affiliation:

B Kenarova

Abstract:

The immunomodulatory activity of ginsenoside Rg1 from Panax ginseng was studied in mice using sheep red cells as the antigen. It was found that ginsenoside Rg1 at a dose of 10 mg/kg administered for three consecutive days before immunization increased the number of spleen plaque-forming cell, the titers of sera hemagglutinins as well as the number of antigen-reactive T-cells. Ginsenoside Rg1 also increased the number of T-helper cells with respect to the whole T-cell number and the splenocyte natural killer activity. Ginsenoside Rg1 induced an augmentation of the production of IL-1 by macrophages and exerted a direct mitogenic effect on microcultured thymus cells. Ginsenoside Rg1 also partly restored the impaired immune reactivity by cyclophosphamide treatment.

Study Type : In Vitro Study

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