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Abstract Title:

Efficacy and safety of oral administration of a product based on hydroxytyrosol as preventive therapy for recurrent vulvo-vaginal candidosis: a prospective observational pilot study.

Abstract Source:

Eur Rev Med Pharmacol Sci. 2020 Jul ;24(13):7427-7432. PMID: 32706082

Abstract Author(s):

M A Zullo, M C Schiavi, A Di Pinto, G Prata, M Scudo, P Luffarelli, C Oliva

Article Affiliation:

M A Zullo

Abstract:

OBJECTIVE: The aim of the study is to evaluate the efficacy and safety of hydroxytyrosol for the prevention of the vulvar vaginal candida infections recurrence.

PATIENTS AND METHODS: This study is a prospective observational pilot study. Eligible subjects were at least 18 years old, with at least 4 documented episodes of vulvovaginal candidiasis in the last 12 months. Patients were instructed to therapy (2 tabs daily for the first month and then 1 tab daily for 2 other months). Each capsule consists of hydroxytyrosol (HT) and other components: tea tree oil, tabebuia, juglans regia, and copper. Clinical and microbiological assessments took place at baseline and 12 weeks after. The impact on Quality of Life (QoL) was evaluated with the SF-36 and the Patient Global Impression of Improvement (PGI-I) after 3 months of treatment was calculated.

RESULTS: Sixty patients were enrolled in the study. In the last 1 year the mean number of previous infections was 5.83± 2.76. Forty-nine patients (83%) did not have candida episodes during 3 months of treatment. A significant reduction in clinical symptoms, vaginal signs, such as pruritus, burning and vulvar erythema (<0.0001). The SF-36 showed a significant change (55.67±8.43 vs. 84.56±11.56, p<0.0001) and the total success at PGI-I was reported in 54 patients (90%).

CONCLUSIONS: The HT-based product is effective and safe in preventing recurrent candida episodes and improves the quality of life and sexual function of treated women.

Study Type : Human Study

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Sayer Ji
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