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Abstract Title:

Hydrogen-rich water improves cognitive impairment gender-dependently in APP/PS1 mice without affecting Aβ clearance.

Abstract Source:

Free Radic Res. 2018 Dec ;52(11-12):1311-1322. Epub 2018 Apr 23. PMID: 29683360

Abstract Author(s):

Chen Hou, Yunhua Peng, Chuan Qin, Fan Fan, Jiankang Liu, Jiangang Long

Article Affiliation:

Chen Hou

Abstract:

Alzheimer's disease (AD) is characterised as a provoked inflammatory response and oxidative stress along with amyloidβ peptide (Aβ) deposition and neurofibrillary tangles in the brain, and effective treatment is greatly needed. Molecular hydrogen, which has been proposed to be an antioxidant that selectively reduces reactive oxygen species, was found to exert beneficial effects in Aβ injection-induced cognitivedysfunction. However, whether and how hydrogen affects AD pathogenesis remains uninvestigated. Thus, in the present study, APPswe/PS1dE9 (amyloid precursor protein (APP)/PS1) mice, a transgenic AD mouse model, were administered hydrogen-rich water for 3 months and the effects on cognitive functionand molecular pathways were investigated. We found that hydrogen-rich water significantly improved cognitive behaviour in female transgenic AD mice without affecting Aβ clearance, and reversed the brain oestrogen level, ERβ, and brain-derived neurotrophic factor (BDNF) expressions that were damaged in female transgenic AD mice, but not in males. Furthermore, hydrogen-rich water ameliorated oxidative stress and inflammatory responses more profoundly in the brains of female AD mice than in those of males. Our results demonstrate a novel sex-specific beneficial effect of hydrogen via oestrogenand brain ERβ-BDNF signalling in AD pathogenesis.

Study Type : Animal Study

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