n/a
Article Publish Status: FREE
Abstract Title:

Honokiol Protects against Anti-1-Adrenergic Receptor Autoantibody-Induced Myocardial Dysfunction via Activation of Autophagy.

Abstract Source:

Oxid Med Cell Longev. 2018 ;2018:1640804. Epub 2018 Jul 18. PMID: 30116474

Abstract Author(s):

Xi-Qing Wei, Hong-Sheng Zhang, Guang-He Wei, Jin-Guo Zhang, Yan-Yan Du, Hong-Yong Tan, Jun Yang

Article Affiliation:

Xi-Qing Wei

Abstract:

Myocardial diseases are prevalent syndromes with high mortality rate. The exploration of effective interference is important. Anti-1-adrenergic receptor autoantibody (1-AAB) is highly correlated with myocardial dysfunction. The actions and underlying mechanisms of honokiol (HNK) in1-AAB-positive patients await to be unraveled. In this study, we established a rat model of1-AAB positive with myocardial dysfunction. Cardiac function following1-AR-ECII administration was analyzed using the VisualSonics Vevo 770 High-Resolution In Vivo Imaging System. The levels of autophagy-related proteins were detected by Western blotting. Our data revealed that HNK reversed1-AAB-induced effects and protected myocardial tissues from dysfunction. After HNK treatment, the cardiac contractile ability increased and the LDH activity decreased. HNK attenuated myocardial degeneration. In addition, HNK promoted the activation of the AMP-dependent protein kinase/Unc-51-like autophagy activating kinase (AMPK/ULK) pathway and activated autophagy. These results suggest that HNK protects against1-AAB-induced myocardial dysfunction via activation of autophagy and it may be a potentially therapeutic compound for1-AAB-positive myocardial diseases.

Study Type : In Vitro Study

Print Options


Key Research Topics

Sayer Ji
Founder of GreenMedInfo.com

Subscribe to our informative Newsletter & get Nature's Evidence-Based Pharmacy

Our newsletter serves 500,000 with essential news, research & healthy tips, daily.

Download Now

500+ pages of Natural Medicine Alternatives and Information.

This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.

© Copyright 2008-2020 GreenMedInfo.com, Journal Articles copyright of original owners, MeSH copyright NLM.