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Article Publish Status: FREE
Abstract Title:

Honokiol Ameliorates Amyloidosis and Neuroinflammation and Improves Cognitive Impairment in Alzheimer's Disease Transgenic Mice.

Abstract Source:

J Pharmacol Exp Ther. 2018 Sep ;366(3):470-478. Epub 2018 Jul 10. PMID: 29991481

Abstract Author(s):

Dongmei Wang, Xiaohui Dong, Chenying Wang

Article Affiliation:

Dongmei Wang

Abstract:

The present study examined the effects of honokiol on amyloid-(A)-induced cognitive impairment and the underlying mechanisms in APPswe/PS1dE9 transgenic mice. The results showed that honokiol administration (20 mg/kg per day, intraperitoneally) for 6 weeks effectively improved spatial memory deficits in APPswe/PS1dE9 transgenic mice. Honokiol significantly lowered Aproduction and senile plaque deposition by downregulating-site amyloid precursor protein cleavage enzyme 1 and enhancing Aphagocytosis by microglia. Honokiol reduced glial cell activation and the production of proinflammatory cytokines (TNF-, IL-1, and IL-6). Honokiol increased the transcriptional activity and protein levels of peroxisome proliferator-activated receptor-(PPARHowever, all of the beneficial effects of honokiol on pathologic changes, including biochemistry and cognitive function, could be blocked by GW9662, a specific PPARinhibitor. These findings suggested that honokiol may be a natural PPARagonist, acting to attenuate Ageneration and neuroinflammation. Therefore, honokiol may be a potential therapeutic approach for Alzheimer's disease.

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