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Abstract Title:

Hispolon decreases melanin production and induces apoptosis in melanoma cells through the downregulation of tyrosinase and microphthalmia-associated transcription factor (MITF) expressions and the activation of caspase-3, -8 and -9.

Abstract Source:

Int J Mol Sci. 2014 Jan 17 ;15(1):1201-15. Epub 2014 Jan 17. PMID: 24445257

Abstract Author(s):

Yi-Shyan Chen, Shu-Mei Lee, Chih-Chien Lin, Chia-Yi Liu

Article Affiliation:

Yi-Shyan Chen

Abstract:

Hispolon is one of the most important functional compounds that forms Phellinus linteus (Berkeley& Curtis) Teng. Hispolon has antioxidant, anti-inflammatory, antiproliferative and anticancer effects. In this study, we analyzed the functions of hispolon on melanogenesis and apoptosis in B16-F10 melanoma cells. The results demonstrated that hispolon is not an enzymatic inhibitor for tyrosinase; rather, it represses the expression of tyrosinase and the microphthalmia-associated transcription factor (MITF) to reduce the production of melanin inα-melanocyte-stimulating hormone (α-MSH)-stimulated B16-F10 cells at lower concentrations (less than 2 μM). In contrast, at higher concentration (greater than 10 μM), hispolon can induce activity of caspase-3, -8 and -9 to trigger apoptosis of B16-F10 cells but not of Detroit 551 normal fibroblast cells. Therefore, we suggest that hispolon has the potential to treat hyperpigmentation diseases and melanoma skin cancer in the future.

Study Type : In Vitro Study

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