Article Publish Status: FREE
Abstract Title:

High-fat diet-induced metabolic syndrome and oxidative stress in obese rats are ameliorated by yogurt supplementation.

Abstract Source:

Sci Rep. 2019 Dec 27 ;9(1):20026. Epub 2019 Dec 27. PMID: 31882854

Abstract Author(s):

Shoumen Lasker, Md Mizanur Rahman, Faisal Parvez, Mushfera Zamila, Pintu Miah, Kamrun Nahar, Fariha Kabir, Surovi Binte Sharmin, Nusrat Subhan, Gias U Ahsan, Md Ashraful Alam

Article Affiliation:

Shoumen Lasker


The main objective of this experiment was to determine the effects of yogurt supplementation on fat deposition, oxidative stress, inflammation and fibrosis in the liver of rats with high-fat (HF) diet-induced obesity. Male Wistar rats were used in this study and were separated into the following four different groups: the control, control + yogurt, high fat and high fat+ yogurt groups. The high fat groups received a HF diet for eight weeks. A 5% yogurt (w/w) supplement was also provided to rats fed the HF diet. Yogurt supplementation prevented glucose intolerance and normalized liver-specific enzyme activities in the HF diet-fedrats. Yogurt supplementation also significantly reduced the levels of oxidative stress markers in the plasma and liver of HF diet-fed rats. Moreover, inflammatory cell infiltration, collagen deposition and fibrosis in the liver of HF diet-fed rats were also prevented by yogurt supplementation. Furthermore, yogurt supplementation normalized the intestinal lining and brush border in HF diet-fed rats. This study suggests that yogurt supplementation potentially represents an alternative therapy for the prevention of metabolic syndrome in HF diet-fed rats.

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