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Abstract Title:

Hexane fraction from Brazilianleaves improved oral carbohydrate tolerance and inhibitsα-amylase and α-glucosidase activities in diabetic mice.

Abstract Source:

Nat Prod Res. 2020 Feb 24:1-4. Epub 2020 Feb 24. PMID: 32091240

Abstract Author(s):

Dionísio Henrique Amaral da Silva, Humberto de Moura Barbosa, Raphaelle Lima de Almeida Beltrão, Clarissa de França Oliveira Silva, Celuane Alves Moura, Rosane Nora Castro, Jackson Roberto Guedes da Silva Almeida, Dayane Aparecida Gomes, Eduardo Carvalho Lira

Article Affiliation:

Dionísio Henrique Amaral da Silva

Abstract:

popularly known as mulberry, has been traditionally used as anti-diabetic herbal medication. This study focused on hexane fraction from Brazilianleaves (Hex-Mn) effects on digestion and absorption of carbohydrate in diabetic mice. The high-performance liquid chromatography (HPLC) analysis was performed, and showed the presence of flavonoids isoquercetin and kaempferol-3--rhamnoside. Hex-Mn did not alter oral glucose tolerance test; however, it prevented hyperglycemia in oral sucrose and starch tolerance test in diabetic mice. Also, Hex-Mn was more efficient to inhibit theα-glucosidase, showing lower inhibitory effect on α-amylase activity. The results suggest that Hex-Mn may delay the carbohydrate digestion, but not glucose transport through brush border membrane of the intestine, which contribute with reduction in postprandial hyperglycemia in mice. Hex-Mn has antihyperglycemic effect by attenuating the carbohydrate digestion in diabetic mice, which could be explained, at least in part, by the presence of isoquercetin and kaempferol-3--rhamnoside.

Study Type : Animal Study

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