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Abstract Title:

Hepatoprotective effect of Raspberry ketone and white tea against acrylamide-induced toxicity in rats.

Abstract Source:

Drug Chem Toxicol. 2020 Jun 1:1-9. Epub 2020 Jun 1. PMID: 32482111

Abstract Author(s):

Soha M Hamdy, Zakaria El-Khayat, Abdel Razik Farrag, Ola N Sayed, Mervat M El-Sayed, Diaa Massoud

Article Affiliation:

Soha M Hamdy

Abstract:

The current investigation was accomplished to evaluate the hepatoprotective effect of White tea and Raspberry Ketone against toxicity induced by acrylamide in rats. Sixty adult male rats were divided randomly into group (I) control; group (II) rats received RK with dose (6 mg/kg/day); Group III: rats received 5 ml of WT extract/kg/day; Group IV rats received AA (5 mg/kg/day); Group V: rats administrated with both AA (5 mg/kg/day) and RK (6 mg/kg/day) and Group VI: rats administrated AA (5 mg/kg/day) and 5 ml of WT extract/kg/day. The biochemical assaysexhibited a significant increase in serum levels of Adiponectin, AST, ALT, ALP of the group treated with acrylamide if compared to the control group and an improvement in their levels of groups V and VI. The histopathological and immunohistochemical findings confirm the biochemical observations. Inconclusion, the present investigation proved that the supplementation of WT and RK enhanced the liver histology, immunohistochemistry and biochemistry against the oxidative stress induced by acrylamide.

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