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Article Publish Status: FREE
Abstract Title:

Hemp (L.) Protein Hydrolysates Promote Anti-Inflammatory Response in Primary Human Monocytes.

Abstract Source:

Biomolecules. 2020 May 22 ;10(5). Epub 2020 May 22. PMID: 32456009

Abstract Author(s):

Noelia M Rodriguez-Martin, Sergio Montserrat-de la Paz, Rocio Toscano, Elena Grao-Cruces, Alvaro Villanueva, Justo Pedroche, Francisco Millan, Maria C Millan-Linares

Article Affiliation:

Noelia M Rodriguez-Martin

Abstract:

Hemp seeds have a wide variety of chemical compounds which present biological activity. Specifically, the focus on proteins and bioactive peptides are increasing as alternative sources of nutraceutical uses. In the literature, hemp protein products (HPPs) have reported antioxidant and anti-inflammatory properties. This study aimed to determine the inflammation-related modulatory effects of HPPs on lipopolysaccharide (LPS)-activated primary human monocytes. CD14cells were immunomagnetically isolated from buffy coats and the anti-inflammatory activity of hemp protein isolate (HPI) and hydrolysates (HPHs) was evaluated on LPS-stimulated human primary monocytes. The specific markers of inflammation, polarization, and chemoattraction were measured by RT-qPCR and ELISA assays. Our results showed that HPPs decreased the pro-inflammatory mediators (,, and) and increased the anti-inflammatory mediators (and). In addition, M1 polarization marker gene expression (and) was downregulated by HPPs and, M2 polarization marker gene expression (and) was upregulated. Finally, the mRNA expression of chemotaxis genes (and) was downregulated by HPPs. In conclusion, this study suggests that HPPs may improve chronic inflammatory states and promote regenerative processes by reprogramming monocytes toward M2 polarization phenotype.

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