Abstract Title:

Antihypertensive effects of Gynura procumbens extract in spontaneously hypertensive rats.

Abstract Source:

J Med Food. 2006;9(4):587-90. PMID: 17201650

Abstract Author(s):

Mi-Ja Kim, Hee Jae Lee, Sumali Wiryowidagdo, Hye Kyung Kim

Article Affiliation:

Department of Obesity Management, Graduated School of Obesity Science, Dongduk Women's University, Seoul, Republic of Korea.

Abstract:

Aqueous extracts of Gynura procumbens (Lour.) Merr. were orally administered to spontaneously hypertensive (SHR) rats for 4 weeks, and antihypertensive effects were determined. Oral administration of 500 mg/kg of G. procumbens (Lour.) Merr. extract (GPE) resulted in significantly lower blood pressure in SHR rats compared with SHR rats not given GPE (P<.05). Furthermore, GPE-administered rats had significantly lower serum lactate dehydrogenase, creatine phosphate kinase, and increased nitric oxide (NO), a known vasodilator, compared with the non-GPE-administered SHR group (P<.05). These results suggest that oral administration of aqueous GPE may be useful for prevention and treatment of hypertension through increasing NO production in blood vessels.

Study Type : Animal Study

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