Abstract Title:

Chemopreventive effects of Paullinia cupana Mart var. sorbilis, the guaraná, on mouse hepatocarcinogenesis.

Abstract Source:

Cancer Lett. 2006 Feb 20;233(1):158-64. PMID: 15885883

Abstract Author(s):

Heidge Fukumasu, Tereza Cristina da Silva, José Luis Avanzo, Cyntia Esteves de Lima, Ivone Isabel Mackowiak, André Atroch, Helenice de Souza Spinosa, Fernando Salvador Moreno, Maria Lucia Zaidan Dagli

Abstract:

Guaraná (Paullinia cupana) is originally from Amazon, Brazil. Its effects on mouse hepatocarcinogenesis have been investigated in this study. Mice were treated with N-nitrosodiethylamine (DEN), received three different doses of P. cupana added to commercial food, and euthanized after 25 weeks. Gross lesions were quantified, and preneoplastic lesions (PNL) were histologically measured. Cellular proliferation was evaluated by immunobloting for the proliferating cell nuclear antigen (PCNA). The incidence and multiplicity of macroscopic lesions were reduced. The PNL number and PCNA expression were reduced in the highest P. cupana dose. According to these results, guaraná presented inhibitory effects on DEN hepatocarcinogenesis in mice.

Study Type : Animal Study
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