Article Publish Status: FREE
Abstract Title:

Ginsenoside Rh2 improves learning and memory in mice.

Abstract Source:

J Med Food. 2013 Aug ;16(8):772-6. PMID: 23957360

Abstract Author(s):

Jingang Hou, Jianjie Xue, Mira Lee, Lei Liu, Dongliang Zhang, Mengqi Sun, Yinan Zheng, Changkeun Sung

Article Affiliation:

Jingang Hou


A wide range of plant foods and dietary supplements are able to modify the functioning of the central nervous system. In the present study, we observed that oral administration of ginsenoside Rh2 (10 mg/mL) for 3 weeks significantly improved spatial learning and memory. Spatial memory and learning was evaluated in mice by hippocampus-dependent tasks (Morris water maze test) and immunohistochemical marker of cell genesis bromodeoxyuridine. Ginsenoside Rh2 treatment (30 days) promoted cell survival and genesis. Further, ginsenoside Rh2 treatment in enriched condition had no significant effects on cell survival compared with standard condition exposure. These results revealed that ginsenoside Rh2-mediated spatial learning and memory improvement was associated with cell genesis and survival and may be parallel to the mechanism of environmental enrichment. Therefore, ginsenoside Rh2 may have efficacy as a dietary supplement for spatial learning and memory improvement.

Study Type : Animal Study

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