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Article Publish Status: FREE
Abstract Title:

A Preclinical Systematic Review of Ginsenoside-Rg1 in Experimental Parkinson's Disease.

Abstract Source:

Oxid Med Cell Longev. 2017 ;2017:2163053. Epub 2017 Mar 13. PMID: 28386306

Abstract Author(s):

Liang Song, Meng-Bei Xu, Xiao-Li Zhou, Dao-Pei Zhang, Shu-Ling Zhang, Guo-Qing Zheng

Article Affiliation:

Liang Song

Abstract:

To date, no drug has been proven to be neuroprotective or disease-modifying for Parkinson's disease (PD) in clinical trials. Here, we aimed to assess preclinical evidence of Ginsenosides-Rg1 (G-Rg1), a potential neuroprotectant, for experimental PD and its possible mechanisms. Eligible studies were identified by searching six electronic databases from their inception to August 2016. Twenty-five eligible studies involving 516 animals were identified. The quality score of these studies ranged from 3 to 7. Compared with the control group, two out of the 12 studies of MPTP-induced PD showed significant effects of G-Rg1 for improving the rotarod test (<0.01), two studies for improving the swim-score values (<0.01), six studies for improving the level of TH protein expression (<0.01), and two studies for increasing the expression of TH mRNA in the substantia nigra of mice (<0.01). The studies reported that G-Rg1 exerted potential neuroprotective effects on PD model through different mechanisms as antineuroinflammatory activities (= 10), antioxidant stress (= 3), and antiapoptosis (= 11). In conclusion, G-Rg1 exerted potential neuroprotective functions against PD largely by antineuroinflammatory, antioxidative, and antiapoptotic effects. G-Rg1 as a promising neuroprotectant for PD needs further confirmation by clinical trials.

Study Type : Review

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Sayer Ji
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