Abstract Title:

Anti-neuroinflammation effect of ginsenoside Rbl in a rat model of Alzheimer disease.

Abstract Source:

Neurosci Lett. 2011 Jan 3;487(1):70-2. Epub 2010 Oct 7. PMID: 20933058

Abstract Author(s):

Yulin Wang, Jing Liu, Zhongmin Zhang, Pengxiang Bi, Zhiguo Qi, Chaodong Zhang

Article Affiliation:

China Medical University, The First Affiliated Hospital, Department of Neurology, Shen Yang, China.


The present work explored the anti-neuroinflammation effects of Ginseng Rb1 in a rat model of Alzheimer disease produced by ventricle injection of Aβ1-42. Aβ1-42 injection induces loss of learning and memory behavior of rats in Morris water maze, which could be reversed with Rb1 treatment. Further, Rb1 reversed the changes in several direct or indirect neuroinflammation markers in the hippocampus, suggesting that this could be a potential underlying mechanism and a way to develop anti-aging drugs.

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