Abstract Title:

Ginsenoside 20(S)-protopanaxadiol attenuates depressive-like behaviour and neuroinflammation in chronic unpredictable mild stress-induced depressive rats.

Abstract Source:

Behav Brain Res. 2020 May 25:112710. Epub 2020 May 25. PMID: 32464121

Abstract Author(s):

Ning Jiang, Lv Jingwei, Haixia Wang, Hong Huang, Qiong Wang, Guirong Zeng, Shanshan Li, Xinmin Liu

Article Affiliation:

Ning Jiang


20 (S)-protopanaxadiol (PPD) possesses a variety of biological activities, including antioxidant, antifatigue and anti-inflammatory properties. This study was aimed to investigate the antidepressant-like effects of PPD and potential mechanisms in rats exposed to chronic unpredictable mild stress (CUMS) model. Results showed that chronic treatment with PPD for 14 days ameliorated depressive-like behaviour, as indicated by the increase in sucrose preference in the sucrose preference test and decrease in immobility in the forced swim test and tail suspension test. In addition, PPD decreased the elevated levels of CORT and proinflammatory cytokines (IL-6, IL-1β and TNF-α) in the serum and neurotransmitters (5-HT and NE) in the hippocampus and PFC induced by CUMS. PPD suppressed the microglial activation in the DG induced by CUMS. Furthermore, our results suggested that rats treated with PPD displayed decreased iNOS, COX2, cleaved-caspase3, cleaved-caspase9, Bax, Bcl-2, and ac-p65 levels and increased Sirt1 levels in the hippocampus. In conclusion, this study indicated that PPD exerts promising antidepressant-like effects in CUMS rats that are mediated in part through alterations in the dysfunction of the HPA axis, the normalization of the levelsof neurotransmitters, and the suppression of neuronal apoptosis and neuroinflammation, possibly through the regulation of the SIRT1/NF-kB signalling pathway.

Print Options

Key Research Topics

Sayer Ji
Founder of GreenMedInfo.com

Subscribe to our informative Newsletter & get Nature's Evidence-Based Pharmacy

Our newsletter serves 500,000 with essential news, research & healthy tips, daily.

Download Now

500+ pages of Natural Medicine Alternatives and Information.

This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.

© Copyright 2008-2021 GreenMedInfo.com, Journal Articles copyright of original owners, MeSH copyright NLM.