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Abstract Title:

Genomic Instability Decreases in HIV Patient by Complementary Therapy withExtracts.

Abstract Source:

J Med Food. 2020 Mar 3. Epub 2020 Mar 3. PMID: 32125929

Abstract Author(s):

Blanca Patricia Lazalde-Ramos, Ana Lourdes Zamora-Perez, Aymée Ileana Ortega-Guerrero, Saira Zulema Quintero-Fraire, Omar Palacios-Lara, Sol María Quirarte-Báez, Carlos Galaviz-Hernández, Martha Sosa-Macías, Yveth Marlene Ortiz-García, Gabriela Morales-Velazquez

Article Affiliation:

Blanca Patricia Lazalde-Ramos

Abstract:

Genomic instability is associated with increased oxidative stress in patients with human immunodeficiency virus (HIV). The aim of this study was to determine the effect of intake of methanolic and aqueous extractson genomic instability in HIV patients. We studied 67 HIV patients under pharmacological treatment with ATRIPLA who were divided into three groups: group 1, patients under ATRIPLA antiretroviral therapy; group 2, patients with ATRIPLA and rosemary aqueous extract (4 g/L per day); and group 3, patients with ATRIPLA and rosemary methanolic extract (400 mg/day). The genomic instability was evaluated through the buccal micronucleus cytome assay. Oral epithelial cells were taken at the beginning and 1 and 4 months later. The groups that received the pharmacological therapy with ATRIPLA and the complementary therapy withextracts showed a decrease in the number of cells with micronuclei and nuclear abnormalities compared with the group that only received ATRIPLA. The complementary therapy withdecreased the genomic instability in HIV patients.

Study Type : Human Study
Additional Links
Pharmacological Actions : Genoprotective : CK(413) : AC(148)

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