Abstract Title:

Gastrodin alleviates memory deficits and reduces neuropathology in a mouse model of Alzheimer's disease.

Abstract Source:

Neuropathology. 2014 Aug ;34(4):370-7. Epub 2014 Mar 25. PMID: 24661139

Abstract Author(s):

Yikui Hu, Chengyan Li, Wei Shen

Article Affiliation:

Yikui Hu


Alzheimer's disease (AD) is a progressive, neurodegenerative disease, characterized by excessive accumulation of amyloid-beta (Aβ) and activation of microglia cells and astrocytes. In this research, we evaluated whether gastrodin, an active component isolated from the rhizome of Gastrodia elata, has neuroprotective effects in a mouse model of AD, Tg2576 mice. Treatment of gastrodin (60 mg/kg for 15 days) significantly improved memory impairments in the Morris water maze test and probe test. Moreover, immunohistochemical and ELISA results indicated that gastrodin significantly attenuated Aβ deposition and glial activation in brains of these transgenic mice. These findings suggested that gastrodin exerted neuroprotective activity via anti-inflammatory and anti-amyloidogenic effects and that gastrodin may be a potential option for AD therapy.

Study Type : Animal Study

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