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Article Publish Status: FREE
Abstract Title:

Galectin-3 Inhibition With Modified Citrus Pectin in Hypertension.

Abstract Source:

JACC Basic Transl Sci. 2021 Jan ;6(1):12-21. Epub 2021 Jan 6. PMID: 33532663

Abstract Author(s):

Emily S Lau, Elizabeth Liu, Samantha M Paniagua, Amy A Sarma, Giovanna Zampierollo, Begoña López, Javier Díez, Thomas J Wang, Jennifer E Ho

Article Affiliation:

Emily S Lau

Abstract:

We investigated the effect of galectin-3 (Gal-3) inhibition with modified citrus pectin on markers of collagen metabolism in a proof-of-concept randomized placebo-controlled trial of participants with elevated Gal-3 levels and hypertension. Although higher Gal-3 levels were associated with female sex, diabetes, and reduced glomerular filtration rate in cross-sectional analyses, treatment with modified citrus pectin did not change collagen markers. The effect of Gal-3 inhibition among individuals with heart failure warrants further investigation.

Study Type : Human Study

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