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Abstract Title:

Fucoidan-based micelles as P-selectin targeted carriers for synergistic treatment of acute kidney injury.

Abstract Source:

Nanomedicine. 2020 Nov 27 ;32:102342. Epub 2020 Nov 27. PMID: 33253922

Abstract Author(s):

Gaofeng Shu, Chenying Lu, Zhixian Wang, Yuyin Du, Xiaoling Xu, Min Xu, Zhongwei Zhao, Minjiang Chen, Yiyang Dai, Qiaoyou Weng, Shiji Fang, Kai Fan, Di Liu, Yongzhong Du, Jiansong Ji

Article Affiliation:

Gaofeng Shu

Abstract:

Acute kidney injury (AKI) is a life-threatening disease without effective treatment. The utilization of curcumin (Cur) for the treatment of AKI is still facing challenges due to its poor water-solubility and low bioavailability. Herein, kidney-targeted octenyl succinic anhydride-grafted fucoidan loaded with Cur (OSA-Fucoidan/Cur) was fabricated for synergistic treatment of AKI. It was found that OSA-Fucoidan/Cur micelles had a sustained drug release behavior and excellent physicochemical stability. Cellular uptake studies demonstrated that the specific binding between fucoidan and P-selectin overexpressed on HO-stimulated HUVECs contributed to the higher internalization of OSA-Fucoidan/Cur micelles by the cells. In addition, OSA-Fucoidan micelles exhibited an ideal kidney-targeted characteristic in lipopolysaccharide (LPS)-induced AKI mice. In vivo studies showed that the combination of Cur and OSA-Fucoidan endowed the OSA-Fucoidan/Cur micelles with synergistically anti-inflammatory and antioxidant abilities, thereby largely enhancing the therapeutic efficacy of AKI. Therefore, OSA-Fucoidan/Cur micelles may represent a potential kidney-targeted nanomedicine for effective treatment of AKI.

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