Article Publish Status: FREE
Abstract Title:

In vitro inhibition of Toxoplasma gondii by four new derivatives of artemisinin.

Abstract Source:

Antimicrob Agents Chemother. 2006 Dec ;50(12):4206-8. Epub 2006 Oct 23. PMID: 17060514

Abstract Author(s):

Lorraine Jones-Brando, John D'Angelo, Gary H Posner, Robert Yolken

Article Affiliation:

Lorraine Jones-Brando

Abstract:

Toxoplasmosis, caused by the protozoan Toxoplasma gondii, is medically important and distributed worldwide. Currently available medications are limited in terms of efficacy and side effects. We synthesized novel, nonacetal, hydrolytically stable derivatives of artemisinin and showed that they inhibit the replication of Toxoplasma gondii in cell culture.

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