n/a
Article Publish Status: FREE
Abstract Title:

Fisetin regulates gut microbiota to decrease CCR9/CXCR3/CD4T-lymphocyte count and IL-12 secretion to alleviate premature ovarian failure in mice.

Abstract Source:

Am J Transl Res. 2020 ;12(1):203-247. Epub 2020 Jan 15. PMID: 32051749

Abstract Author(s):

Jiajia Lin, Xiaoli Nie, Ying Xiong, Zhangbin Gong, Jiulin Chen, Chuan Chen, Yongyi Huang, Te Liu

Article Affiliation:

Jiajia Lin

Abstract:

Currently, there are no studies reporting the efficacy of fisetin in premature ovarian failure (POF). In this study, using mouse andmodels, we found that fisetin not only significantly reversed ovarian damage in POF mice, but also effectively increasedlifespan and fertility. Subsequently, we carried out 16S rRNA v3+v4 sequencing using fresh feces samples from each group of mice. Results showed that although there was no significant difference in the number of gut microbiomes between the different groups of mice, fisetin affected the diversity and distribution of gut microbiota in POF mice. Alpha and beta diversity analyses showed that in the gut of POF mice in the fisetin group, the bacterial count of uncultured_bacterium_f_Lachnospiraceae was significantly increased, while that ofwas significantly decreased. Finally, flow cytometry analysis showed that the numbers of CCR9/CXCR3/CD4T lymphocytes in the peripheral blood of POF mice in the fisetin group were significantly reduced, along with the number of CD4/interleukin (IL)-12cells. Therefore, our data suggested that fisetin regulates the distribution and bacterial counts ofand uncultured_bacterium_f_Lachnospiracea in POF mice, and reduces peripheral blood CCR9/CXCR3/CD4T-lymphocyte count and IL-12 secretion to regulate the ovarian microenvironment and reduce inflammation, thus exerting therapeutic effects against POF.

Study Type : Animal Study

Print Options


Key Research Topics

Sayer Ji
Founder of GreenMedInfo.com

Subscribe to our informative Newsletter & get Nature's Evidence-Based Pharmacy

Our newsletter serves 500,000 with essential news, research & healthy tips, daily.

Download Now

500+ pages of Natural Medicine Alternatives and Information.

This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.

© Copyright 2008-2020 GreenMedInfo.com, Journal Articles copyright of original owners, MeSH copyright NLM.