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Abstract Title:

[Fecal microbiota transplantation as a novel therapy for severe psoriasis].

Abstract Source:

Zhonghua Nei Ke Za Zhi. 2019 Oct 1 ;58(10):782-785. PMID: 31594178

Abstract Author(s):

G Yin, J F Li, Y F Sun, X Ding, J Q Zeng, T Zhang, L H Peng, Y S Yang, H Zhao

Article Affiliation:

G Yin

Abstract:

To explore the therapeutic effect of fecal microbiota transplantation (FMT) for severe psoriasis. A patient, male, 36 years old, diagnosed as severe plaque psoriasis for 10 years and irritable bowel syndrome (IBS) for 15 years, was administrated twice FMT via both upper endoscopy and colonoscopy with a 5-week interval. The following items were used to evaluate responses: body surface area (BSA), psoriasis area and severity index (PASI), dermatology life quality index (DLQI), histological examination, intestinal symptoms, adverse reactions and serum level of tumor necrosis factor (TNF)-α. After second FMT treatment for 5 weeks, aforementioned items were improved greatly compared with those before treatment. Moreover, IBS was completely relieved and no adverse reactions were observed during the treatment and follow-up. In conclusion, FMT could be a novel therapy for psoriasis. Further clinical trials are needed to provide solid evidences.

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