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Article Publish Status: FREE
Abstract Title:

Exploring the Promise of Flavonoids to Combat Neuropathic Pain: From Molecular Mechanisms to Therapeutic Implications.

Abstract Source:

Front Neurosci. 2020 ;14:478. Epub 2020 Jun 9. PMID: 32587501

Abstract Author(s):

Md Sahab Uddin, Abdullah Al Mamun, Md Ataur Rahman, Md Tanvir Kabir, Saad Alkahtani, Ibtesam S Alanazi, Asma Perveen, Ghulam Md Ashraf, May N Bin-Jumah, Mohamed M Abdel-Daim

Article Affiliation:

Md Sahab Uddin

Abstract:

Neuropathic pain (NP) is the result of irregular processing in the central or peripheral nervous system, which is generally caused by neuronal injury. The management of NP represents a great challenge owing to its heterogeneous profile and the significant undesirable side effects of the frequently prescribed psychoactive agents, including benzodiazepines (BDZ). Currently, several established drugs including antidepressants, anticonvulsants, topical lidocaine, and opioids are used to treat NP, but they exert a wide range of adverse effects. To reduce the burden of adverse effects, we need to investigate alternative therapeutics for the management of NP. Flavonoids are the most common secondary metabolites of plants used in folkloric medicine as tranquilizers, and have been claimed to have a selective affinity to the BDZ binding site. Several studies in animal models have reported that flavonoids can reduce NP. In this paper, we emphasize the potentiality of flavonoids for the management of NP.

Study Type : Review
Additional Links
Pharmacological Actions : Analgesics : CK(2569) : AC(470)

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