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Abstract Title:

α-Glucosidase inhibitors from the stems of Embelia ribes.

Abstract Source:

Phytother Res. 2014 Nov ;28(11):1632-6. Epub 2014 May 21. PMID: 24849650

Abstract Author(s):

Phu Hoang Dang, Hai Xuan Nguyen, Nhan Trung Nguyen, Hanh Ngoc Thi Le, Mai Thanh Thi Nguyen

Article Affiliation:

Phu Hoang Dang

Abstract:

From the ethyl acetate extract of the stems of Embelia ribes (Myrsinaceae), a new alkenylresorcinol, embeliphenol A (1), together with 11 known compounds have been isolated. Their structures were elucidated on the basis of spectroscopic data. All compounds possessed significantα-glucosidase inhibitory activity in a concentration-dependent manner, except for 2 and 9. Compounds 1, 3-6, 8, and 12 showed more potent inhibitory activity, with IC50 values ranging from 10.4 to 116.7 μM, than that of a positive control acarbose (IC50 , 214.5 μM).

Study Type : In Vitro Study

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