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Abstract Title:

α-Glucosidase inhibitors from the leaves of Embelia ribes.

Abstract Source:

Fitoterapia. 2015 Jan ;100:201-7. Epub 2014 Dec 16. PMID: 25527005

Abstract Author(s):

Phu Hoang Dang, Nhan Trung Nguyen, Hai Xuan Nguyen, Luan Bao Nguyen, Tho Huu Le, Truong Nhat Van Do, Mao Van Can, Mai Thanh Thi Nguyen

Article Affiliation:

Phu Hoang Dang

Abstract:

A novel and rare 1,4-dehydrated ceramide, embelamide (1), and a new C-glycoalkaloid which is based on aβ-carboline ring system, 1-(2'-deoxy-α-d-ribopyranosyl)-β-carboline (4), were isolated from the CHCl3 soluble fraction of the leaves of Embelia ribes (Myrsinaceae), together with thirteen known compounds (2-3, 5-15). Their structures were elucidated on the basis of spectroscopic data. Compounds 1, and 5-12 possessed significant α-glucosidase inhibitory activity in a concentration-dependent manner, and showed more potent inhibitory activity, with IC50 values ranging from 1.3 to 155.0 μM, than that of a positive control acarbose (IC50, 214.5 μM).

Study Type : In Vitro Study

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