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Article Publish Status: FREE
Abstract Title:

Electronic Cigarette Aerosol Modulates the Oral Microbiome and Increases Risk of Infection.

Abstract Source:

iScience. 2020 Feb 13:100884. Epub 2020 Feb 13. PMID: 32105635

Abstract Author(s):

Smruti Pushalkar, Bidisha Paul, Qianhao Li, Jian Yang, Rebeca Vasconcelos, Shreya Makwana, Juan Muñoz González, Shivm Shah, Chengzhi Xie, Malvin N Janal, Erica Queiroz, Maria Bederoff, Joshua Leinwand, Julia Solarewicz, Fangxi Xu, Eman Aboseria, Yuqi Guo, Deanna Aguallo, Claudia Gomez, Angela Kamer, Donna Shelley, Yindalon Aphinyanaphongs, Cheryl Barber, Terry Gordon, Patricia Corby, Xin Li, Deepak Saxena

Article Affiliation:

Smruti Pushalkar

Abstract:

The trend of e-cigarette use among teens is ever increasing. Here we show the dysbiotic oral microbial ecology in e-cigarette users influencing the local host immune environment compared with non-smoker controls and cigarette smokers. Using 16S rRNA high-throughput sequencing, we evaluated 119 human participants, 40 in each of the three cohorts, and found significantly altered beta-diversity in e-cigarette users (p = 0.006) when compared with never smokers or tobacco cigarette smokers. The abundance of Porphyromonas and Veillonella (p = 0.008) was higher among vapers. Interleukin (IL)-6 and IL-1β were highly elevated in e-cigarette users when compared with non-users. Epithelial cell-exposed e-cigarette aerosols were more susceptible for infection. In vitro infection model of premalignant Leuk-1 and malignant cell lines exposed to e-cigarette aerosol and challenged by Porphyromonas gingivalis and Fusobacterium nucleatum resulted in elevated inflammatory response. Our findings for the first time demonstrate that e-cigarette users are more prone to infection.

Study Type : Human Study
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Additional Keywords : Risk Factors : CK(3057) : AC(392)

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