n/a
Article Publish Status: FREE
Abstract Title:

Efficacy and Safety of the Combination of Superoxide Dismutase, Alpha Lipoic Acid, Vitamin B12, and Carnitine for 12 Months in Patients with Diabetic Neuropathy.

Abstract Source:

Nutrients. 2020 Oct 23 ;12(11). Epub 2020 Oct 23. PMID: 33114210

Abstract Author(s):

Triantafyllos Didangelos, Eleni Karlafti, Evangelia Kotzakioulafi, Zisis Kontoninas, Charalampos Margaritidis, Parthena Giannoulaki, Konstantinos Kantartzis

Article Affiliation:

Triantafyllos Didangelos

Abstract:

AIM: To investigate the efficacy of Superoxide Dismutase, Alpha Lipoic Acid, Acetyl L-Carnitine, and Vitamin B12 (B12) in one tablet in Diabetic Neuropathy (DN).

PATIENTS-METHODS: In this prospective, double-blind, placebo-controlled study, 85 patients with Diabetes Mellitus Type 2 (DMT2) were randomly assigned, either to receive the combination of four elements (active group,= 43), or placebo (= 42) for 12 months. We used the Michigan Neuropathy Screening Instrument Questionnaire and Examination (MNSIQ and MNSIE), measured the vibration perception threshold (BIO), and Cardiovascular Autonomic Reflex Tests (CARTs). Nerve function was assessed by DPN Check [sural nerve conduction velocity (SNCV) and amplitude (SNAP)]. Pain (PS) and quality of life (QL) questionnaires were administered.

RESULTS: At follow-up, BIO, MNSIQ, QL, PAIN, and SNCV, SNAP, and B12 levels had significantly improved inactive group (<0.001,<0.001,<0.001,<0.001,= 0.027,= 0.031, and<0.001 respectively), whereas the inplacebo group MCR (mean circular resultant) and PAIN deteriorated (<0.001,<0.001). The changes in MNSIQ, QL, SNCV, BIO, and PAIN differed significantly between groups (<0.001,<0.001,= 0.031,<0.001, and<0.001 respectively).

CONCLUSIONS: The combination of the four elements in one tablet for 12 months in patients with DMT2 improved all indices of peripheral neuropathy, including SNAP and SNCV, pain, and Quality of Life perception, except CARTs and MNSIE.

Study Type : Human Study

Print Options


Key Research Topics

Sayer Ji
Founder of GreenMedInfo.com

Subscribe to our informative Newsletter & get Nature's Evidence-Based Pharmacy

Our newsletter serves 500,000 with essential news, research & healthy tips, daily.

Download Now

500+ pages of Natural Medicine Alternatives and Information.

This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.

© Copyright 2008-2021 GreenMedInfo.com, Journal Articles copyright of original owners, MeSH copyright NLM.