Article Publish Status: FREE
Abstract Title:

Effects of vitamin C and E on toxic action of alcohol on partial hepatectomy-induced liver regeneration in rats.

Abstract Source:

J Clin Biochem Nutr. 2018 Jul ;63(1):50-57. Epub 2018 Apr 3. PMID: 30087544

Abstract Author(s):

Yurika Okamura, Akira Omori, Norihiko Asada, Akifumi Ono

Article Affiliation:

Yurika Okamura


The purpose of this study was to investigate the influence of vitamins C and E on the toxic action of alcohol in rat liver regeneration. Male Sprague-Dawley rats subjected to 70% partial hepatectomy were divided into five groups (Groups 1 to 5). Rats in Groups 2 to 5 were only provided alcohol for drinking. Additionally, vitamin C, vitamin E, and vitamin C in combination with vitamin E were administered to Groups 3, 4, and 5, respectively. Alcohol inhibits liver regeneration, resulting in an increase in free radicals produced by alcohol metabolism and thus causing cellular damage and altering liver function. During liver regeneration, vitamins C and E significantly ameliorated liver injury from alcohol administration by reducing hepatic lipid peroxidation. Vitamins C and E protect against liver injury and dysfunction, attenuate lipid peroxidation, and thus may be more effective in combination than either vitamin alone against alcohol-mediated toxic effects during liver regeneration.

Study Type : Animal Study

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